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A field with wild flowers is an allegory of biosustainability. Biological sustainability is focusing on the development of the concept of microbial cell factories for a sustainable bio-production of chemicals replacing the classical chemical processes. The goal is to increase the chemical diversity of the products which may be produced in microbes. The extensive chemical diversity found in the plant kingdom is developed by dedicated research on plant biochemistry and genetics. The triumvirate of increased chemical diversity, in silico design, and an expanded cell factory portfolio defines the next generation of microbial and plant cell factories, which will be instrumental in the transition to the bio-based society