4th Annual Biotechnology Lecture and Awards

Date Friday, October 08, 2010, 13:00 - 16:00
Location Hannover Auditorium, Panum Institute, University of Copenhagen, Blegdamsvej 3B, Copenhagen N
Organizers Biokemisk Forening and Dansk Bioteknologisk Selskab


Session I: Annual Biotechnology Lecture

13.00 – 13.10

Lars Juhl Jensen, Disease Systems Biology, NNF Centre for Protein Research, University of Copenhagen, Panum Institute: Presentation of 4th Annual Biotechnology Lecture.

13.10 – 14.00

Bernhard Palsson, Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA: The meta-structure of the E. coli genome and its genome-scale
transcriptional regulatory network.

14.00 – 14.30

Coffee break


Session II: Annual Biotechnology Awards for Young Researchers

14.30 – 14.40

Steen Gammeltoft, Glostrup Hospital, Denmark: Presentation of 4th Annual Biotechnology Awards for Young Researchers.

14.40 – 15.00

Dimitrios Stamou, Bio-Nanotechnology Laboratory, Nano-Science Center, University of Copenhagen: Lipid-Membrane Biotechnology and Synthetic Biology on the Nanoscale.

15.00 – 15.20

Tina Hummelshøj Glue, Department of Clinical Immunology, Rigshospitalet: The Ficolins - new defence players of the innate immune system.

15.20 – 15.40

Karl, Agger, BRIC, Biocenter, University of Copenhagen: Erasing the histone methylation mark: Identification and characterization of histone demethylases.

15.40 – 16.00

Reception and refreshments

acrobat_icon Download flyer for the symposium


The meta-structure of the E. coli genome and its genome-scale transcriptional regulatory network

BO Palsson, Department of Bioengineering, UCSD, La Jolla CA

Regulation of gene expression is widely considered to be a core issue in biology. Normally such studies have focused on a single gene or a group of genes. Advances in ChIP-chip technology now enable us to study this issue on a genome scale. We have obtained close to a 100 ChIP-chip data sets for E. coli K-12 MG1655 that include; RNAP, the sigma factors, most of the broad acting transcription factors (TFs), and the majority of the nucleoid associated protein (NAPs). In addition we have obtained tiling array data for expression profiling and transcription start site (TSS) data from short read sequencing technology. Degradation start sites (DSS) are obtained by a variation of the TSS protocol. This data enables us to 1) formulate the metastrucure (that is comprised of the functional, structural and operational annotation) of the E. coli genome and 2) to draft the reconstruction of the transcriptional regulatory network (TRN) in E. coli at a genome-scale.